Innate immune cell responses in non pathogenic versus pathogenic SIV infections
نویسندگان
چکیده
منابع مشابه
Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization
Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected macaques, whereas natural reservoir hosts exhibit limited disease and pathology. It is, however, unclear how natural hosts can sustain high viral loads, comparable to those observed in the pathogenic model, without developing severe disease. We performed transcriptional profiling on lymph node, blood, and col...
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Infections with mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis (M. bovis) BCG, are a leading cause of morbidity and mortality for HIV-infected persons. In contrast to HIV, nonpathogenic SIV infections of sooty mangabeys are characterized by a lack of clinical disease including an absence of opportunistic infections. The goal of this study was to identify innate...
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The last 5 years have seen a remarkable extension of the innate immune system starting with what seemed at the time primarily cells that exert their influence during ontogeny of the immune system. So-called lymphoid tissue inducer (Lti) cells were soon joined by RORgt expressing innate lymphoid cells (ILC) that shaped immune responses beyond the determination of lymphoid architecture (Sawa et a...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2016
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2016.06.011